Sodium Methyl P-Hydroxybenzoate
Methyl 4-hydroxybenzoate,sodium salt
CAS: 5026-62-0
Molecular Formula: C8H7NaO3
Sodium Methyl P-Hydroxybenzoate - Names and Identifiers
| Name | Methyl 4-hydroxybenzoate,sodium salt |
| Synonyms | METHYLPARABEN SODIUM SODIUM METHYL PARABEN Methyl Paraben Sodium METHYLPARABEN, SODIUM SALT Methyl paraben,sodium salt METHYL 4-HYDROXYBENZOATE SODIUM Methyl 4-hydroxybenzoate sodium Sodium Methyl P-Hydroxybenzoate (p-carboxyphenoxy)-sodiumethylester sodium 4-(methoxycarbonyl)phenolate methyl p-hydroxybenzoate sodium salt METHYL 4-HYDROXYBENZOATE SODIUM SALT Methyl 4-hydroxybenzoate sodium salt Methyl 4-hydroxybenzoate,sodium salt benzoicacid,4-hydroxy-,methylester,sodiumsalt 4-hydroxybenzoic acid methyl ester sodium salt |
| CAS | 5026-62-0 |
| EINECS | 225-714-1 |
| InChI | InChI=1/C8H8O3.Na/c1-11-8(10)6-2-4-7(9)5-3-6;/h2-5,9H,1H3;/q;+1/p-1 |
| InChIKey | PESXGULMKCKJCC-UHFFFAOYSA-M |
Sodium Methyl P-Hydroxybenzoate - Physico-chemical Properties
| Molecular Formula | C8H7NaO3 |
| Molar Mass | 174.13 |
| Density | 1.42 g/cm3 (20 °C) |
| Melting Point | >125°C |
| Boling Point | 265.5°C at 760 mmHg |
| Flash Point | 116.4°C |
| Water Solubility | 418g/L at 20℃ |
| Solubility | Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| Vapor Presure | 0.00555mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| BRN | 4165000 |
| pKa | 8.4[at 20 ℃] |
| PH | 9.7-10.3 (1g/l, H2O) |
| Storage Condition | Store at +15°C to +25°C. |
| MDL | MFCD00016470 |
| Physical and Chemical Properties | White hygroscopic powder, soluble in water, alkaline. |
| Use | Widely used in medicine, food, textile industry and other fields such as anti-corrosion of cosmetics, feed, daily industrial products |
Sodium Methyl P-Hydroxybenzoate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | DH2455000 |
| HS Code | 29182930 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
Sodium Methyl P-Hydroxybenzoate - Standard
Authoritative Data Verified Data
This strain is refined by adding methyl p-hydroxybenzoate to an aqueous solution of sodium hydroxide. Calculated as anhydrous, the content of C8H7Na03 should be 98. 0% ~ 102. 0%.
Last Update：2024-01-02 23:10:35
Sodium Methyl P-Hydroxybenzoate - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder.
- This product is soluble in water, slightly soluble in ethanol, and almost insoluble in dichloromethane.
Last Update：2022-01-01 11:25:50
Sodium Methyl P-Hydroxybenzoate - Differential diagnosis
Authoritative Data Verified Data
- Take 10mg of this product, put it in a test tube, add 10. 6% sodium carbonate solution lm l, heated and boiled for 3 0 seconds, let cool, add 0.1% 4-aminoantipyrine Borate Buffer (pH 9. 0) (take 0. 618% boric acid 0. lmol/L potassium chloride solution 1000ml with 0. 5.3% mol/L sodium hydroxide solution mixed with ml) 5ml and potassium ferricyanide solution lm l, mixed well, the solution turned red.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- identification reaction of sodium salt of this product (General rule 0301).
Last Update：2022-01-01 11:25:50
Sodium Methyl P-Hydroxybenzoate - Exam
Authoritative Data Verified Data
alkalinity
take 0.10g of this product, add 0631 of water to dissolve, and determine according to law (general rule),p H value should be 9. 5~10. 5.
clarity and color of solution
take this product l.O g, add 0901 of water to dissolve, check according to law (General rule 0901 and General Rule 0 9 0 2 ), the solution should be clarified; Color and Brown Red 3 Standard Colorimetric solution (General rule first method) comparison, not deeper.
chloride
take this product 2. O g, add water 40ml to dissolve, adjust the solution to Neutral with dilute nitric acid, dilute to 50 m l with water, shake, filter, take filtrate 5. O m l, checked according to law (General rule 0801), with standard gasified sodium solution 7.0ml of the control solution should not be more concentrated (0.035%).
sulfate
take 25ml of the filtrate under the chloride item and check it according to the law (General rule 0802). Compared with the control solution made of standard potassium sulfate solution m, it should not be deeper (0. 024%).
Related substances
take an appropriate amount of this product, add the mobile phase to dissolve and dilute to make each lml containing l.O m g solution, as the test solution; Precision take the appropriate amount, diluted with the mobile phase to make a solution containing 10 liters per lm l, as a control solution. According to the chromatographic conditions under the content determination item, take the control solution 20jxl, inject the human liquid chromatograph, adjust the detection sensitivity, the peak height of the main component chromatographic peak is about 20% of the full scale> and then 20 u1 of the test solution and the control solution are accurately measured, and the human liquid chromatograph is injected respectively, the chromatogram was recorded to 4 times the retention time of the main component peak. If there is a peak consistent with the retention time of the p-Hydroxybenzoic acid peak in the chromatogram of the test solution, the peak area of 1 .4 times should not be greater than 3 times the main peak area of the control solution (3 .0% ) , the peak area of other single impurities should not be greater than 0 of the main peak area of the control solution. 5 times (0. 5), the sum of the peak areas of other impurities shall not be greater than the main peak area of the control solution (1 .0%).
moisture
take this product, according to the determination of moisture (General rule 0832 first method 1) determination, containing no more than 5 .0% moisture.
Heavy metals
take 0821g of this product and check it according to law (General rule 4.0 method); If the test solution is colored and cannot be colored with thin caramel, take g of this product, add 10ml of sodium hydroxide solution and 20ml of water, then divide them into two equal parts, add water to make it 25m l in tube B, add 5 drops of sodium sulfide solution in tube A, and shake well, filter through filter membrane (pore size 3pm), then add 2ml of standard lead solution in tube A and add water to make 25ml, then add 5 drops of sodium sulfide test solution in two tubes of a and B respectively, for comparison, heavy metals should not be more than 10 parts per million.
arsenic salt
take this product l.O g, add lg of calcium hydroxide, mix, add 2ml of water, stir evenly, after drying, slowly burn to complete charring with small fire, then burn to gray-white at 500~600 "C, let cool, add hydrochloric acid 5ml with water 23M l, inspection according to law (General Principles 0822 The first law), should comply with the provisions (0.0002%).
Last Update：2022-01-01 11:25:51
Sodium Methyl P-Hydroxybenzoate - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system applicability test using eighteen alkyl silane bonded silica gel as filler; Methanol -1% glacial acetic acid (60:40) as mobile phase, the detection wavelength was 254nm. The mixed solution containing 0.lm g per lml of sodium hydroxybenzyl Ester and p-Hydroxybenzoic acid was prepared by adding flow matching, and 20ul was injected into the liquid chromatograph to record the chromatogram, the resolution of p-Hydroxybenzoic acid peak and sodium phenylhydroxymethyl Ester peak should meet the requirements.
- The determination method is to take an appropriate amount of this product, precisely weigh it, add the mobile phase to dissolve and quantitatively dilute it into a solution containing 0.lm g of sodium hydroxybenzyl Ester per lm l. The precise amount is to take 20ful and inject it into human liquid chromatograph, the chromatogram was recorded, and an appropriate amount of reference substance of methyl hydroxybenzoate was taken and determined by the same method. According to the external standard method, the peak area is multiplied by the coefficient of 1 .145 and then calculated.
Last Update：2022-01-01 11:25:52
Sodium Methyl P-Hydroxybenzoate - Category
Authoritative Data Verified Data
pharmaceutical excipients, bacteriostatic agents.
Last Update：2022-01-01 11:25:52
Sodium Methyl P-Hydroxybenzoate - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:25:52
Sodium Methyl P-Hydroxybenzoate - Reference Information
| LogP | -0.63 at 20℃ |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | water-soluble preservatives are used in dairy products, pickles, beverages, fruit juices, jellies and cakes (the maximum amount is the same as propyl paraben). Widely used in the anti-corrosion of medicine, food, textile industry and other fields such as cosmetics, feed, and daily industrial products |
| spontaneous combustion temperature | >600°C |
Last Update：2024-04-09 15:16:50
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